Oral Thin Films (OTFs) are well established as an important non-invasive route for drug administration. Placed on or under the tongue or buccally, they are absorbed by the oral mucosa with the active substance directly transported into the bloodstream.<\/p>\n\n\n\n
From opioid dependence therapies to antiemetics, a variety of over the counter (OTC) and prescription products have played to the strengths of this technology. All of them can be seen to facilitate a comparatively rapid onset of action via a convenient, simple and water-free method of drug delivery, a combination that has obvious advantages for paediatric, geriatric and dysphagic populations, where the act of swallowing is difficult and compliance can, as a result, be poor.<\/p>\n\n\n\n
In recent years, the scientific community has continued to expand its understanding of the potential for OTFs and further optimise an already effective drug delivery platform. This includes addressing questions around physical characteristics, patient acceptability, dissolution rate, speed of onset, drug loading capacity, and stability under broad environmental conditions.<\/p>\n\n\n\n
This innovative study was designed to assess whether a foam-based structure provides advantages over the more traditional types of OTF. Foam based OTFs are classified with the fast-disintegrating film category, featuring a single layer film based on soluble hydrophilic polymers, designed for sublingual, lingual or buccal application. Disintegration is within 60 seconds.<\/p>\n\n\n\n
The more traditional types of OTF include\u2026
\u2022 Slow or non-disintegrating buccal film
A multi-layer film based on low soluble and insoluble polymers, designed for gingival or buccal application. Disintegration of the muco-adhesive layer is within one hour.
\u2022 Melt-away film
Single- or multi-layer film based on soluble polymers, designed for gingival, buccal or sublingual delivery. Disintegration is within a few minutes.<\/p>\n\n\n\n
Dr. Katharina Dauer of LTS was part of this study and in March 2026, at the 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (PBP World Meeting) in Prague, she presented a poster documenting investigations into a foam-based OTF concept.<\/p>\n\n\n\n
The study detailed the methodology of the foaming process. This involved using oxygen, nitrogen, or air, to aerate the bulk mixture, which is composed of the active pharmaceutical ingredient (API), polymer, plasticiser, sweetener and flavouring agents.<\/p>\n","protected":false},"excerpt":{"rendered":"
OTFs are well established as an important non-invasive route for drug administration. Placed on or under the tongue or buccally, they are absorbed by the oral mucosa with the active substance directly transported into the bloodstream.<\/p>\n","protected":false},"author":3,"featured_media":30567,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[27],"tags":[],"class_list":["post-30566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-white-paper"],"_links":{"self":[{"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/posts\/30566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/comments?post=30566"}],"version-history":[{"count":1,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/posts\/30566\/revisions"}],"predecessor-version":[{"id":30568,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/posts\/30566\/revisions\/30568"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/media\/30567"}],"wp:attachment":[{"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/media?parent=30566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/categories?post=30566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ltslohmann.com\/en\/wp-json\/wp\/v2\/tags?post=30566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}