IN VITRO PERMEATION STUDIES. Expertise so real, it’s palpable

The core proposition of any transdermal or oromucosal drug delivery system is the patches or films’ ability to deliver the API effectively, efficiently, accurately and safely. In order to assess the effectiveness of a range of dermal, transdermal and microneedle technologies, LTS established its pioneering ‘skin lab’, dedicated to the assessment of the cutaneous permeation of molecules in support of the development of new formulations and the repurposing of existing therapies.

Trusted by clients worldwide, our team of experienced experts have over 30 years in this specialized space and are supported by a dedicated laboratory equipped with state-of-the-art technologies and techniques. Combined, this ensures the highest standards of process and outcomes to support our pharma partners in formulation development and regulatory submission.

Our permeation services were developed according to OECD, FDA, and EMA guidelines and include GMP-certified IVPT studies. And, our proprietary in vitro permeation test is a proven bioequivalence model, accepted by the leading regulatory authorities including EMA, FDA and PDMA.

There is another element to our ‘skin lab’ beyond the science. It is a tangible and material passion for the subject. Our desire to deliver the right outcomes is visceral. This emotional intelligence drives the team every day to discover and improve our offer, always focused on the endgame and never losing sight of the patient need.

Key services for pharmaceutical partners

  • Regulatory studies according to OECD TG 428, EMA, FDA and PDMA guidelines
  • Investigation of local distribution at application site
  • Analysis of absorption, distribution and metabolism
  • Metabolites toxicokinetic and local tolerance on fully viable tissues
  • Investigation of oromucosal delivery in LTS proprietary designs
  • HPLC-MS/MS, UPLC analytical techniques and validation
  • Test compounds: pharmaceuticals (API), substance based medical devices, cosmetics
  • Individually designed trials according to the pharma partner’s specific brief

Specific questions about our skinlab and skinlab offerings?

Please get in contact with us.